Satellite PK/PD modeling workshops

The University Hospital of Cologne is hosting two satellite workshops prior to and following the 14th European ISSX Meeting.

Review the satellite workshop details below and please note that registration for these workshops is organized through the university and not ISSX. Please do not make any travel arrangements before receiving confirmation from the satellite workshop organizers.

 
 
Monday, 26 June | 09:00 - 12:30

One-Day Workshop: Physiologically-Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Modeling with PK-Sim/MoBi

As part of the workshop, hands-on sessions and case studies will be offered to familiarize the participants with the workflow and technicalities associated with Physiologically-Based Pharmacokinetic and Pharmacodynamic (PBPK/PD) Modeling.

Target Audience: Pharmacometric analysis is progressively becoming an indispensable tool in drug development and clinical care. The course is intended for participants with limited or basic knowledge of PK/PD modeling who wish to use this tool for informing and rationalizing decisions by introducing them to some of the state-of-art tools in pharmacometrics.

Location: The University Hospital of Cologne, Center of Pharmacology, Cologne Germany.

Date: 25th June, 2017, 09:00 - 17:00

Instructors: The course will technically be organized by the Clinical Pharmacology Unit in the University Hospital of Cologne, led by Prof. Uwe Fuhr, and tutored by the Bayer Systems Pharmacology team (head: Dr. Thomas Eißing).

Language: English

Workshop Outline:

  • Introduction to the concept of PBPK modeling and application areas of PBPK
  • Hands-on PBPK exercises with PK-Sim (software will be provided to registrants)
  • PD and systems pharmacology modeling with PK-Sim/MoBi
  • Future development of systems pharmacology platform PK-Sim/MoBi – input of users on future needs

Computers will not be provided and therefore we kindly ask you to bring your own laptops with you. Software is best downloaded and installed beforehand (instructions will follow, see http://www.systems-biology.com/products/pk-sim/). The installation and license key will be provided. Attendees will need admin rights on their computers for installation.

Workshop Fees:

  • 400 € for participants from industry and commercial enterprises
  • 200 € for academics and participants from non-profit organizations
  • 100 € for students in MSc or PhD programs.

Registration: Please send an e-mail to max.taubert@uk-koeln.de; detailed information, participation confirmation, and instructions for payment will follow as soon as a sufficient number of participants is reached.

Please DO NOT make any travel arrangements before receiving a confirmation.

 
Monday, 26 June | 13:30 - 17:00

Three-Day Workshop: The Third Workshop on Non-Linear Mixed Effects Modeling using NONMEM® for Beginners - 2017

This workshop aims to introduce the basic concepts and principles of non-linear mixed effects modeling using NONMEM and other assisting software suites (e.g. PsN, Xpose & Pirana). As part of the workshop, hands-on sessions and case studies will be offered to familiarize the participants with the workflow and technicalities associated with population modeling such as data management, model coding, and interpretation of the results.

Target Audience: Pharmacometric analysis is progressively becoming an indispensable tool in drug development and clinical care. The course is intended for participants with limited or basic knowledge of PK/PD modeling who wish to use this tool for informing and rationalizing decisions by introducing them to some of the state-of-art tools in pharmacometrics.

Location: The University Hospital of Cologne, Center of Pharmacology, Cologne, Germany.

Date: 30th June to 2nd July, 2017

Instructors: The course will be organized by the Clinical Pharmacology Unit in the University Hospital of Cologne, and tutored by young dynamic tutors (actual and former members of the team) who have demonstrated their solid experience and profound knowledge by numerous publications in international journals and conferences. Through multiple research projects, they have used modeling and simulation to address different questions relevant to drug development and to the clinic. Examples of their work included analyzing data from different sources (preclinical, phases-I, -II & -III studies), of different nature (continuous, categorical and time-to-event), and for different purposes (physiologically-based pharmacokinetics, mechanism-based pharmacodynamics, and survival).

Language: English

Workshop Outline:

  • Introduction to (non-)linear regression modeling: basic statistical principles, least squares and maximum likelihood fitting, fixed and random effects, first order (conditional) estimation.
  • Introduction to population pharmacokinetic modeling: introduction to NONMEM files (control stream and data file), structural model development, random effects modeling.
  • Model evaluation: introduction to supporting software tools (e.g. R, Xpose, PsN), goodness-of-fit plots, residual diagnostics, bootstrapping analysis, simulation based diagnostics (e.g. visual predictive checks).
  • Covariate model building
  • Introduction to modeling pharmacodynamics: different pharmacodynamic models, linking pharmacokinetics to pharmacodynamics

Computers will not be provided and therefore we kindly ask you to bring your own laptops with you and we will provide the necessary software on USB sticks.

Workshop Fees:

  • 1200 € for participants from industry and commercial enterprises
  • 600 € for academics and participants from non-profit organizations
  • 300 € for students in MSc or PhD programs.

Registration: please send an e-mail to max.taubert@uk-koeln.de; participation confirmation and instructions for payment and will follow as soon as a sufficient number of participants is reached.

Please DO NOT make any travel arrangements before receiving a confirmation.


Feedback from previous workshops:

“Instructors were experienced and well-informed. They were also patient with questions”
“What I really liked about this workshop was the hands-on sessions”
“Material was excellent, and the tutors made an excellent introduction to NONMEM